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Upstream Bio, Inc. Share Price

Upstream Bio, Inc. Share Price

NASDAQ: UPB | Micro Cap
$4.61
+$0.03 (0.66%) Last updated on 08 Oct, 2026 | 01:29 IST
  • Performance
  • Chart
  • Fundamentals
  • Quarterly P&L
  • Annual P&L
  • About
  • Price history
  • FAQs

Upstream Bio, Inc. Stock Performance

Open
$4.54
Prev. Close
$4.58
Circuit Range
N/A
Day Range
$4.53 - $4.67
Year Range
$4.53 - $33.58
Volume
56,590
Average Traded
$4.59

Upstream Bio, Inc. Share Price Today

As of 8 October 2026, Upstream Bio, Inc.'s share price is $4.61. The stock opened at $4.54, compared to its previous close of $4.58. During today's trading session, Upstream Bio, Inc.'s share price traded between $4.53 and $4.67, with an average price of $4.60. Over the past 52 weeks, the stock has recorded a high of $33.58 and a low of $4.53. In terms of performance, Upstream Bio, Inc.'s share price has declined by 49.73% over the last six months and is down 82.16% on a year-on-year basis.

Upstream Bio, Inc. Share Price Chart

$4.53$4.67
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Upstream Bio, Inc. Stock Fundamentals & Key Indicators

Market Cap
$248.26M
PE Ratio (TTM)
N/A
Dividend Yield
0.00%
EPS (TTM)
$-2.86
Revenue (TTM)
$2.85B
Return On Equity (TTM)
-57.76%
Profit Margin
-5032.98%
Debt to Equity
0.00
Quarterly Earnings Growth YoY
-17.63%

Upstream Bio, Inc. Quarterly Profit & Loss

All figures in USD

ParticularsSep 2025Dec 2025Mar 2026Jun 2026
Revenue$0.68$0.67$1.03$0.77
Net Profit-$33.75-$42.46-$40.59-$39.70
Net Profit Margin-4963.24%-6337.31%-3940.78%-5155.84%
Income ChangeN/A-25.81%4.40%2.19%

Upstream Bio, Inc. Annual Profit & Loss

All figures in USD

Particulars20242025
Revenue$2.37$2.85
Net Profit-$76.40-$143.44
Net Profit Margin-3223.63%-5032.98%
Income ChangeN/A-87.75%

About Upstream Bio, Inc.

Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).

Upstream Bio, Inc. Historical Returns

MonthOpenCloseChange %
Oct 2026
$5.18
$4.61
-12.54%
Sep 2026
$6.54
$5.26
-22.46%
Aug 2026
$6.25
$6.79
+7.95%
Jul 2026
$6.95
$6.29
-9.04%
Jun 2026
$8.31
$6.92
-17.24%
May 2026
$9.21
$8.36
-8.89%
Apr 2026
$9.22
$9.17
+2.23%
Mar 2026
$7.58
$8.97
+16.64%
Feb 2026
$31.66
$7.69
-75.25%
Jan 2026
$27.09
$31.07
+14.29%
Dec 2025
$28.32
$27.18
-4.71%
Nov 2025
$25.84
$28.53
+10.41%

UPB Share Price FAQs

What is Upstream Bio, Inc. share price today?

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Upstream Bio, Inc. share price today is $4.61 as on October 8, 2026 at 1:29 am IST.

What is the 52 week high and 52 week low of Upstream Bio, Inc. stock?

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The 52 week high of Upstream Bio, Inc. stock is $33.58, while the 52 week low is $4.53 as of 8 Oct '26.

What is UPB's market capitalisation today?

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UPB market capitalisation is $248.26M as of October 8, 2026, at 4:08 pm IST.

What is UPB's net income for the last quarter?

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UPB's net income for the last quarter is -39.70B USD.

What is the 5 year returns of UPB?

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The 5 year returns of UPB is -81.41% as on 8 Oct '26.

What is the high & low stock price of UPB today?

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UPB stock price hit a high of $4.67 and low of $4.53 as of 8 Oct '26.

Can I buy UPB shares in India?

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Yes. You can buy UPB in India by opening an international trading account.